Arizona Cardinals (4-6) vs San Francisco 49ers (5-4)
Monday, November 21, 2022 at 8:15 pm
With this game being played in Mexico City, a place that is high altitude, and this number approaching double-digits I'm backing the Cardinals in this one. Arizona plays better football away from home and I expect them to attack San Fran's pass defense as they threw the ball 37 times last week. Keep in mind, the last time these teams played, Colt McCoy started and led the Cardinals to a 31-17 victory last November. There's a fair chance he starts as Kyler Murray is dealing with a hamstring injury and with him a HC Cliff Kingsbury having a contentious relationship, the Cardinals brass might not be hard-pressed to put him back on the field just yet. With that being said, I expect a competitive game from these NFC West rivals as this is basically a must-win for Arizona (4-6) and their backs are against the wall in making the playoffs. Take the points.